Here is a link to the paper.
Here is the abstract.
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Background: Knowledge about the impact of occupational exposures, such as work stress, on the risk of atrial fibrillation is limited. The present study aims to investigate the association between job strain, a measure of work stress, and atrial fibrillation.
Design: Prospective cohort study design and fixed-effect meta-analysis.
Methods: Data from the Swedish Longitudinal Occupational Survey of Health (SLOSH) was utilised for the main analysis, combining self-reported data on work stress at baseline with follow-up data on atrial fibrillation from nationwide registers. Cox proportional hazard regression analyses were used to estimate hazard ratios and 95% confidence intervals (CIs). A fixed-effect meta-analysis was conducted to pool the results from the present study with results from two similar previously published studies.
Results: Based on SLOSH data, job strain was associated with an almost 50% increased risk of atrial fibrillation (hazard ratio 1.48, 95% CI 1.00–2.18) after adjustment for age, sex and education. Further adjustment for smoking, physical activity, body mass index and hypertension did not alter the estimated risk. The meta-analysis of the present and two previously published studies showed a consistent pattern, with job strain being associated with increased risk of atrial fibrillation in all three studies. The estimated pooled hazard ratio was 1.37 (95% CI 1.13–1.67). Conclusion: The results highlight that occupational exposures, such as work stress, may be important risk factors for incident atrial fibrillation.
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The estimated hazard ratio of 1.48 is impressive. However, the absolute risk is so small that increasing it by 48% still leaves it very small. According to Table 1 in the paper (assuming I am reading it right), about 1.0 % of the "no strain" people developed atrial fibrillation vs. about 1.3% for the "strain" group.
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The estimated hazard ratio of 1.48 is impressive. However, the absolute risk is so small that increasing it by 48% still leaves it very small. According to Table 1 in the paper (assuming I am reading it right), about 1.0 % of the "no strain" people developed atrial fibrillation vs. about 1.3% for the "strain" group.
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